Caveolae is abundant features of the plasma membrane in many cells. Until now, they are generally considered invaginasi membrane formation is primarily driven by integral membrane proteins called caveolins. However, the last decade has seen the emergence of family Cavin peripheral membrane protein as an important component coat and Yeast Recombinant Proteins regulators of biogenesis caveola. In this Commentary, we summarize recent data on the role in the formation caveola cavins, highlighting structural studies provide new insights into the mantle Cavin assembly. In mammals, there are four members of the family Cavin association through homo and hetero-oligomerisation to form different subcomplexes on caveolae, which can be released into the cell in response to stimuli. Studies from several laboratories have provided a better understanding of the stoichiometric Cavin and the molecular basis for their oligomerisation, as well as identifying the interaction with the mem...